The series of tragic events that Nick (David Giuntoli) experienced at the end of Season 4 of "Grimm" will not only have a lasting effect on him in the new season, but will also affect his close friends and colleagues.

As fans may recall, the Season 4 finale ended with a shocking cliffhanger, after Trubel (Jacqueline Toboni) killed Nick's girlfriend Juliette (Bitsie Tulloch) in order to save him.

During the gripping scene, Nick was about to kill Juliette to avenge his mother's death. However, he was overcome by his love for Juliette and could not find the strength to kill her. That's when Trubel stepped in and fired two arrows into Juliette. After Juliette was shot, Nick cradled his former lover in his arms and watched her die.

While speaking at the 2015 Comic-Con, actor Russell Hornsby, who plays Nick's partner Hank on the show, opened about the tension that will form between Hank and Nick, as Nick copes with the tragic loss of his mother and girlfriend. Not only will this put Nick in a dark state, but it may also change the nature of his relationship with Hank, said Hornsby.

"When you look at what he's lost up to this point, I think there's a lot more at stake then there was even in the first season," said Hornsby about Nick to TV Equals. "When you lose your aunt who didn't know, it doesn't really set off the same amount of emotions as it does as losing your girlfriend and your mother, whom you've fought side by side with," he explained.

According to Hornsby, Nick may become more of a risk taker, which could create a conflict between him and his practical thinking partner.

"There's more of an emotional connection that wasn't there before. So I think we're talking about him taking more chances. And so in that, I hope that there is more conflict between him and Hank," Hornsby said.

TVLine also revealed that "Scream" actress Carlson Young has been cast to play the role of Selina Golias, a woman who gets caught in the middle of an ongoing Wesen feud. Young's character will become targeted by a Wesen "king" after she is forced to hide the survivor of an attack, in which her boyfriend was killed.

Season 5 of "Grimm" will premiere on NBC on Oct. 30.

Watch Hornsby's interview below: