A new poll shows that independent and Hispanic voters would help Democratic presidential candidate Hillary Clinton easily defeat GOP front-runner Donald Trump in a hypothetic general election match-off, but she could still lose against Marco Rubio.

According to a new NBC News/Wall Street Journal poll released on Monday, the Democratic front-runner would win 50 to 40 percent of votes and beat Trump by 10 points. Forty-three percent of independents said they would support Clinton, while only 36 said they are backing the GOP front-runner. Among Hispanics, Clinton would win an overwhelming 69 percent of the vote, compared to just 24 percent for Trump.

Clinton, who leads the Democratic primary field by 19 points, would also beat Republican candidate Sen. Ted Cruz of Texas by 3 points, 48 to 45 percent.

On the other hand, the former secretary of state would lose to Sen. Marco Rubio of Florida by 3 points, 48 to 45 percent, and Ben Carson by 1 point in hypothetical match-ups.

The poll, which surveyed 1,000 adults from Dec. 3 to Dec. 6, reveals that independent voters would back Rubio over the former secretary of state by a 7-point margin. However, Hispanic voters largely favor Clinton over the Cuban-American senator. Clinton would win 59 percent of support from Latinos compared to 36 for Rubio, which gives her a 23-point lead. The former first lady would also win more female voters by a 7 point lead.

National polls show that Rubio has won 15 percent of Republican voters, putting him in third place in the GOP primary race.

A new CNBC Millionaire Survey also shows that Rubio is the top GOP presidential candidate among wealthy voters. However, the general population of American millionaires favors Hillary Clinton.

According to the survey, which questioned wealthy Democrats, Republicans and independents, the former New York senator received 34 percent of support, while Rubio came in second place with 13 percent of backing from rich Americans.