Seattle resident Amanda Knox once again finds her fate in the hands of an Italian court.

Italy's Court of Cassation will make a final decision Wednesday whether Knox's 2009 conviction should stand, or if she should face another trial on appeal, reports ABC News. If convicted, she faces a 28-and-a-half-year prison sentence.

Knox and her co-defendant and former boyfriend, Italian Raffaele Sollecito, have undergone multiple trials for the 2007 killing of British student Meredith Kercher. Kercher shared an apartment with Knox in Perugia, Italy. She was raped and murdered in her bedroom there.

Italian newspaper Gazzetta del Sud reports that the Florence court said in its explanation of the ruling that it heard "reliable" evidence placing Knox and Sollecito in the Perugia flat in "the immediate moments after the murder." A third person, Rudy Guede, a drifter, was convicted of Kercher's killing and is now serving 16 years in prison.

According to the Florence court, Kercher was raped and stabbed to death due to a "mounting quarrel" with Knox, which voids the initial prosecution theory that Kercher was killed during a drug-induced sex game that involved Knox, Sollecito and Guede. Guede's DNA was found inside and on Kercher's body, along with her bedroom, leading to his quick and easy conviction.

Lawyers for Kercher's family will be in court representing them as civil plaintiffs on Wednesday while the family eagerly awaits the court's decision in England, according to Gazzetta del Sud. Their lawyers will request the court reject the appeal as the family believes that Sollecito and Knox are "responsible for the crime."

Sollecito, an Italian citizen, will be present on Wednesday to hear the verdict, while Knox remains in her home city of Seattle, Washington. Sollecito's travel documents were seized after his 2014 conviction. If his conviction is upheld, he most likely will be arrested and faces a 25-year prison sentence.

If the court deems them guilty, Knox could be extradited under a 2006 treaty between Italy and the United States.

"This really has hit me like a train," Knox said during a January 2014 interview with ABC News' Robin Roberts. "I didn't expect this to happen."

In 2009, Knox, 27, was initially convicted. She and Sollectio served four years in prison for the murder but that conviction was overturned on appeal in 2011. The Italian court overturned the acquittal in 2013. Her original conviction was reinstated by the appeals court last year.

In addition, Knox must stand trial on a lesser charge, slander, for claiming Italian police coerced her during their interrogation.

Knox settled in Seattle where she is newly engaged, in therapy, working in a bookstore and writing theater reviews for a local newspaper, reports ABC News.