Swiss tennis superstars Roger Federer and Stan Wawrinka will go up against local bets on Day 8 of the 2015 US Open Tennis Championship at Flushing Meadows in New York.

Federer, the second seed in the men's draw, will go up against 13th seed John Isner of United States in the main game at Arthur Ashe Stadium on Monday night.

Federer, who is coming off an impressive win against 29th seed Philipp Kohlschreiber, has not dropped a set in the tournament, which makes him a heavy favorite heading into his fourth-round assignment.

However, Federer, who is looking to win his 18th Grand Slam title and first since the 2012 Wimbledon, is wary of his 6-foot-10 opponent, who is known for his powerful serves.

"He's got the power," Federer said of Isner. "It needs to be, and then clearly because he's so tall clearly he finds the impossible angles for us, really. And he's got a great second serve, as well. Obviously best-of-three-set match he's even more dangerous. Best-of-five you feel like you have a bit more time."

On the other hand, Stan Wawrinka will also try to book a spot in the quarterfinals. The fifth-seeded Swiss will collide with Donald Young of United States in the second match at Arthur Ashe Stadium.

Wawrinka scored three hard-earned wins in the first three rounds, including his 6-3, 7-5, 6-4 victory against unseeded Ruben Behelmans of Belgium on Saturday.

Young will be a heavy underdog heading into the match, but the 25-year-old proved in the opening round that he is capable of pulling off an upset. The Chicago, Illinois native defeated 11th seed Gilles Simon of France in the first round 2-6, 4-6, 6-4, 6-4, 6-4.

In other notable matches, third seed Andy Murray of Great Britain will go up against 15th seed Kevin Anderson of South Africa, while sixth seed Tomas Berdych of Czech Republic will face 12th seed Richard Gasquet of France at Louis Armstrong Stadium.

In the women's side, second seed Simona Halep of Romania will continue her quest for her first Grand Slam title. She will play 24th seed Sabine Lisicki of Germany in the second match at Louis Armstrong Stadium before the matches featuring Murray and Berdych.

Victoria Azarenka of Belarus will open the festivities at Arthur Ashe Stadium against Varvara Lepchenko of United States, while 5th seed Petra Kvitova of Czech Republic will try to avoid an upset against unseeded Johanna Konta of Great Britain in the first match of the night session.

Complete 2015 US Open Tennis Day 8 schedule and match times are available on this link. Matches will be shown live on ESPN and through online streaming via US Open Live and WatchESPN.