For the second time in a week, U.S. Senate Democrats blocked a Republican resolution disapproving President Barack Obama's historic nuclear agreement with Iran.

Under the U.S.-Iran nuclear deal, which Obama announced in July, the U.S. and a handful of other world powers agreed to lift Iran's economic sanctions. In turn, the Islamic Republic vowed to limit its nuclear program for the next 10 years.

Senate Republicans, however, tried to prevent the deal from going into effect by presenting a disapproval resolution. When presented on the Senate floor for a vote, the majority of Democrats banded together to kill the measure so that Obama would not have to veto it.

According to Reuters, the GOP resolution was four votes shy of getting the 60 votes it needs in order to proceed.

Republicans first brought the resolution of disapproval opposing the agreement to the floor on Friday, September 11. However, by a vote of 58-42, the GOP-controlled Senate fell two votes short of the 60 votes needed in the chamber to advance the legislation.

Following the GOP's second failed effort to stop the nuclear deal from taking effect, Majority Leader Mitch McConnell vowed to make a third attempt to derail it.

The Republican leader declared "debate will continue" over the agreement, reports USA Today.

"At the very least we should be able to provide some protection to Israel and long-overdue relief to Americans who've languished in Iranian custody for years," McConnell said.

Last week, Obama praised Democratic for protesting the landmark legislation.

"The Senate took an historic step forward and voted to enable the United States to work with our international partners to enable the implementation of the comprehensive, long-term deal that will prevent Iran from obtaining a nuclear weapon," he said in a statement issued after the first vote.

"This vote is a victory for diplomacy, for American national security, and for the safety and security of the world."