A severe winter storm is set to bring heavy rain, snow and cold winds to the central U.S. this Thanksgiving weekend.

The Weather Channel reports "Winter Storm Cara" is already accumulating ice, sleet and snow, across the southern and central Plains, complicating holiday travel and knocking out power in some areas. The storm is a result of Artic air from the north meeting a surge of tropical moisture across the Eastern United States.

According to AcuWeather Meteorologist Steve Travis, the storm will likely drop rain across most of Oklahoma, eastern Kansas and western Missouri.

Warnings and advisories are also in place for parts of Texas and New Mexico.

Weather conditions will likely make driving difficult, with downpours reducing visibility, in addition to the threat of icy roads.

To make matters worse, more than 41 million Americans will be driving this holiday weekend, according to the AAA.

"It is certainly going to wreak havoc on the roadways," said Weather Channel forecaster Domenica Davis, via NBC News. "That will be brutal."

While the storm is not expected to intensify to a major snowstorm or blizzard, snowfall is still likely in some areas of the country.

"On the backside of the storm where colder air wraps in, there will be some snow across parts of Minnesota, South Dakota, Nebraska and back into the central Rockies," said Travis.

Strong north winds from 15-30 mph pose the risk of bringing down trees or power lines, which could lead to minor power outages.

Those traveling in the Midwest this weekend are advised to be wary. Travelers heading to eastern cities such as Atlanta, Washington D.C., Philadelphia and New York, are expected to face few difficulties.