Defending World Cup champions Spain will look to bounce back from a humiliating loss in their 2014 FIFA World Cup opener when they collide with Chile on Wednesday at the Estadio Do Maracana in Rio De Jainero.

Spain started the tournament on the wrong foot as they absorbed a lopsided 5-1 loss to Netherlands on Friday, which put them in danger of crashing out of the group stages.

A loss against Chile would virtually eliminate Spain from contention, barring major upsets in the final day of Group B competition, which will make them the first World Cup title holders to get eliminated in the group stages since France suffered the same fate in 2002.

Desperate times call for desperate measures, and Spain coach Vicente del Bosque said that the he will make changes on their starting XI moving forward.

"If they know what the team is in advance, it may change their state of mind," Del Bosque said. "I feel affection for all of these players but above personal feelings we have to find solutions for the team."

According to some reports, Cesc Fabregas could come in for Atletico Madrid star Diego Costa, while Pedro Rodriguez could replace David Silva. Team captain Iker Casillas could also be left out of the starting lineup.

Chile, on the other hand, are expected to go all out in hopes of solidifying their chances of moving into the knockout stages with a win against the defending champions.

Jorge Sampaoli, Chile's coach, is expecting a tough match against Spain, saying that the reigning European champions were in good shape in the first 40 minutes of their match against Netherlands, but the Dutch were simply superior in the second half of the match.

"Look, for 40 minutes Spain were far, far superior to the Netherlands," Sampaoli said via ESPN. "It was just a series of imponderables that led to the huge defeat ... much of the criticism they received was unfair in my opinion. If [David] Silva puts away the chance and makes it two-nil then it's a different game."

The all-important showdown between Spain and Chile will start at 3 p.m. EST. Fans can catch the action on ESPN and via WatchESPN.

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