It's a wrap on Twitter for Director Joss Whedon, who has deleted his Twitter account, following criticism of his latest film, "Avengers: Age of Ultron."

The social media cutoff follows the $191.3 million opening weekend of the highly anticipated film, "which collected the second-highest grossing three-day debut in history -- after only the $207 million opening of Whedon's original Avengers in 2012," according to Time.

Before he disengaged from the Twittersphere, Whedon acknowledged the positive feedback from his fans and tweeted, "Thank you to all the people who've been so kind and funny and inspiring up in here."

So why would Whedon decide to remove himself from the hugely popular social media platform where he has direct contact with his die-hard fans?

Reportedly, for many reasons.

Whedon's Twitter followers and comic book fans weren't shy to criticize the film's plot as well as its portrayal of female characters, calling assassin Black Widow (played by Scarlett Johansson) "sexist and misogynistic" and said he had done a "hatchet job" on Black Widow, also known as Natasha Romanoff, BBC News reports.

Another Twitter follower reportedly asked with the words "strong female character" were not in his vocabulary.

"The most abusive bullying came from viewers who objected to Black Widow's tentative relationship with The Hulk's Bruce Banner and another scene in which she was briefly captured by Ultron," Time points out.

"There was also anger about how he depicted Quicksilver and a number of other plot points that 'fans' of this comic book title apparently felt justified harassment. Filtered out and pasted together, as some on Twitter have done, it looks like significant vitriol -- but compared to the immense volume of conversation about this film on the social media platform, it's really background static."

Yet the Twittersphere got even more dramatic with reported "death threats" that would make anyone want to flee.

"A search of tweets directed at him over the past week definitely turned up some deep ugliness, with some of the abusive users urging him to 'die' or 'commit suicide' over plot points they didn't like in 'Age of Ultron," Time adds. "Although these comments are clearly disturbing, there was no unifying complaint or groundswell of attack beyond just the random (but all-too-typical) viciousness of anonymous social media trolls."

At the same token, many of Whedon's fans have now turned on the critics, subjecting some to harassment and abuse.

Comedian and actor Patton Oswalt accused the haters of causing Whedon to remove himself from the active dialogue, tweeting, "There is a 'Tea Party' equivalent of progressivism/liberalism. And they just chased Joss Whedon off Twitter. Good job, guys. Ugh."

Also in Whedon's defense, "in early April, he issued an apology after tweeting a clip from the forthcoming 'Jurassic World' film was '70s era sexist,' saying his criticism of another person's work in this way had been 'bad form.'"

In the past, Whedon (who was also best known for writing and directing the "Buffy: The Vampire Slayer" TV series) has used his Twitter account as a vehicle to support activist Anita Sarkeesian, "who has done work to highlight the misogyny and sexism in many video games."