Angelina Jolie recently admitted her life with Brad Pitt is far from storybook, and the Hollywood couple have their issues.

The 40-year-old Academy Award-winning actress opened up about her relationship in a Vogue Magazine cover story. She also clarified the upcoming movie "By The Sea," in which she stars with Pitt as a couple in the 1970s, is "not autobiographical."

"Brad and I have our issues, but if the characters were even remotely close to our problems we couldn't have made the film," she added. "As artists, we wanted something that took us out of our comfort zones. Just being raw actors. It's not the safest idea. But life is short."

Jolie directed film, which the couple shot right after saying their "I Dos" at the French Chateau Miraval in August 2014. The project marks the first time they have been on screen together since 2005, when they fell hard for one another on the set of "Mr. & Mrs. Smith."

That must seem like a lifetime ago now, given all the couple has endured since then. Jolie had her ovaries and fallopian tubes removed in March, two years after she underwent a preventative double mastectomy.

"I wish my mom had been able to make those choices," she somberly reflected. "They are not easy surgeries. The ovaries are an easy surgery, but the hormone changes -- interesting."

Jolie's mother Marcheline Bertrand died in 2007 at the age of 56 following an eight-year battle with ovarian and breast cancer. With menopause now behind her, Jolie insisted she is looking forward to growing older and living a long life.

"Both of the women in my family, my mother and my grandmother started dying in their 40s," she said. "I'm 40. I can't wait to hit 50 and know I made it."

The Vogue shoot was done by famed photographer Annie Leibovitz. For the cover, Jolie was joined by Pitt and their six children in pictures that see them running along the beach and posing on bikes together.

"By the Sea" is set for a mid-November release in the U.S.