A-list couple Brad Pitt and Angelina Jolie is truly the epitome of sticking together for better and for worst, in sickness and in health.

In an interview with Today's Tom Brokaw for the couple's upcoming movie "By The Sea," the family patriarch expressed that he is proud of his wife.

After Jolie's mother passed away due to cancer, she has been aware of the possibility that she can as well have it as her grandmother and maternal aunt also died because of the chronic disease. Jolie's discovered in 2013 that she has BRCA1 cancer gene, which gives her 87 percent chance of having breast cancer. It prompted her to undergo a preventive double mastectomy.

"There was no vanity to my wife's approach,'' Pitt told Brokaw, referring to Jolie's surgery. "It was mature. It was just another one of those things in life that makes you tighter, and she was doing it for the kids, and she was doing it for her family so we could be together."

The genetic mutation also gave Jolie a 50 percent chance of having ovarian cancer -- the type of cancer that took the life of her mother Marcheline Bertrand. Last March, her blood tests showed she could have early ovarian cancer signs, which then forced the actress to undergo surgery to remove her ovaries and fallopian tubes. The doctor who took care of Bertrand was also Jolie's surgeon, and the 40-year-old actress said her mother had left their doctor a request: to take care of Jolie's ovaries.

Pitt also shared that he was in France, when Jolie shared the bad news and asked him to return immediately. "Seeing my wife have to be her strongest and knowing that it's the scariest news is terribly moving. And not being there is a horrible feeling," Pitt said.

Knowing that her husband has always been on her side, Jolie was grateful to say that her ordeal did not make her feel "less of a woman" because she knows Pitt won't let her feel that way.

In the couple's new movie, Jolie also shared that some of its plots that were inspired by her own lamentation, when she lost her mother.

According to Daily Mail, "By The Sea" will be the pair's first's film collaboration since 2005's "Mr. and Mrs. Smith." Contrary to the Brangelina's real life relationship, the 1970s set drama revolves around a man and a woman, who are on the brink of separation.

"By The Sea" will be released on Nov. 13 in the U.S.