Argentina will have to make major adjustments in their upcoming World Cup 2014 semifinals clash against Netherlands after Angel Di Maria was ruled out for Wednesday's match.

Multiple reports confirmed that di Maria sustained a thigh injury during their quarter-final victory against Belgium on Saturday.

Argentina team doctor Daniel Martinez told reporters that the star midfielder sustained a first-grade thigh injury, which will be evaluated on a day-to-day basis.

"Angel has a grade one injury. Of course he won't play in Argentina's next game. After that, we'll evaluate the situation day-by-day," Martinez said via Daily Mail.

Di Maria has been playing well for Argentina in this year's World Cup and losing him will be a huge blow for Argentina, who will be making their first World Cup semis appearance in 24 years.

The 26-year-old midfielder scored the game-winning goal in their round-of-16 match against Switzerland, and also assisted Gonzalo Higuain's game-winner in the quarter-final match against Belgium on Saturday.

Good thing for Argentina, star striker Sergio Aguero will be back in action on Wednesday, but it's still unknown at this point whether or not he will be fit enough to start for Alejandro Sabella's squad.

Aguero, who missed two games after also sustaining a muscle strain in his thigh, reportedly participated in Argentina's last three practices, including their training camp on Sunday in Belo Horizonte.

Meanwhile, Argentine superstar Lionel Messi sent a warning to the other three teams in the hunt for this year's World Cup title, saying that they are peaking at the right time.

Messi, who has four goals and one assist in this year's World Cup, said that their performance against Belgium was their best in the tournament. And now that they have broken Argentina's 24-year semis drought, they are hungrier to win it all in Brazil.

"We went over the barrier. We've already succeeded in getting ourselves in the four best teams and we want more," Messi said via Fox Sports. "We've achieved our first objective which was to get to the semi-finals and now we want more. We have to continue with tranquility and think about what's to come, but we are prepared."