Hillary Clinton opened up on the topics of immigration reform, Donald Trump's presidential candidacy and earning the trust of American voters in her first national interview of since entering the 2016 race for the White House.

The Democratic presidential front-runner seemed confident about gaining trust among voters despite recent polls, which showed that over half of Americans do not view Clinton as honest or trustworthy.

"Nearly 6-in-10 Americans say they don't believe that you're honest and trustworthy. Do you understand why they feel that way?" asked CNN's Brianna Keilar during the interview.

In response, Clinton blamed Republicans for spewing a "barrage of attacks" which has created the perception that she is untrustworthy.

"This has been a theme that has been used against me and my husband for many, many years. And at the end of the day, I think voters sort it all out. I have great confidence. I trust the American voter, so I trust the American voter 100 percent, because I think the American voter will weigh these kinds of accusations," she said.

The former secretary of state added that "people should and do trust me."

Later during the interview, Clinton condemned Republican presidential candidate Donald Trump for calling Mexican immigrants drug traffickers and rapists last month.

"I'm very disappointed in those comments and I feel very bad and very disappointed with him and with the Republican Party for not responding immediately and saying, 'Enough, stop it,'" she told Keilar.

Clinton went on to criticize the Republican Party for maintaining what she called a hostile approach to immigration reform. She stated, "They're on a spectrum of hostility, which I think is really regrettable in a nation of immigrants like ours."

The former New York senator also singled out Republican candidate Jeb Bush for his stance on immigration. "He doesn't believe in a path to citizenship. If he did at one time, he no longer does," she said.

Furthermore, Clinton disapproved of the way that San Francisco mishandled the case of an undocumented immigrant who had been deported five times before he murdered a woman in the city.

"The city made a mistake, not to deport someone that the federal government strongly felt should be deported," she said. "I have absolutely no support for a city that ignores the strong evidence that should be acted on."

Watch Clinton's full interview below.