"Grey's Anatomy" is heating up in the kitchen as Meredith throws a dinner party, and of course, it does not go as she had planned. The next episode, titled "Guess Who's Coming to Dinner," is the show's 250th and airs on Thursday, Oct. 22.

In Episode 5, Season 12, Maggie, Meredith's sister, is forced to bail on her cooking duties since she's needed at the hospital, according to Spoilers Guide. This gives April the chance to step in and help cook, which she's glad to do in order to avoid Jackson. Meanwhile Arizona is waiting to find out more details about Callie's new girlfriend.

As Callie arrives to the dinner party she introduces everyone to Penny, the doctor who failed to save Derek's life. This becomes a painful reminder for Meredith, who is scrambling to hide Derek's picture, while Callie and Penny mingle with the other guests.

In the video preview of the episode, Meredith says, "No worries, universe -- I got this!" as she takes on her hosting duties. However, as the party progresses she starts to go from cheery hostess to mischievous host.

Eventually Meredith is expected to face the issue later on in the episode, since this is such a heart wrenching matter for her to endure and because she is reminded of it every time she is in Penny's presence.

This episode is sure to be one of the most dramatic of the entire season.

Callie's all about the introductions, but Meredith already knows exactly who Penny is. #GreysAnatomy

Posted by Grey's Anatomy on Tuesday, October 20, 2015

Stars included in this season of "Grey's Anatomy" include Ellen Pompeo as Meredith, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Kevin McKidd as Owen Hunt, Jessica Capshaw as Arizona Robbins, Jesse Williams as Jackson Avery, Sarah Drew as April Kepner, Caterina Scorsone as Amelia Shepherd, Camilla Luddington as Lo Wilson, Jerrika Hinton as Stephanie Edwards, Kelly McCreary as Maggie Pierce and Jason George as Ben Warren.

"Grey's Anatomy" airs on ABC on Thursday at 8/7c.